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Tunable antibiotic delivery from gellan hydrogels.

Shashank Shukla1, Anita Shukla

  • 1School of Engineering, Center for Biomedical Engineering, Institute for Molecular and Nanoscale Innovation, Brown University, Providence, RI, USA. anita_shukla@brown.edu.

Journal of Materials Chemistry. B
|April 8, 2020
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Summary
This summary is machine-generated.

This study developed novel gellan-based hydrogels for effective antibiotic delivery in wound care. The antibacterial hydrogels demonstrated sustained vancomycin release and inhibited bacterial growth, showing promise for wound infection treatment.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Wound Management

Background:

  • Hydrogels are crucial in wound management, offering localized antibacterial delivery to combat infections.
  • Designing effective antibacterial hydrogels requires preserving antibiotic activity, controlling release kinetics, and ensuring conformability.
  • Gellan, an FDA-approved food additive, presents a potential base for developing advanced wound care materials.

Purpose of the Study:

  • To develop and characterize antibiotic-loaded gellan-based hydrogels for wound therapy.
  • To investigate the influence of hydrogel formulation on mechanical properties and drug release profiles.
  • To evaluate the antibacterial efficacy and biocompatibility of the developed hydrogels.

Main Methods:

  • Gellan hydrogels ('ointment' and 'sheet' formulations) were prepared with varying gellan and CaCl2 concentrations.
  • Vancomycin was encapsulated directly and/or within graphitized carbon black nanoparticles (CNPs).
  • Oscillatory rheology, drug release studies, diffusion modeling (Ritger-Peppas, Peppas-Sahlin), quartz crystal microbalance with dissipation monitoring, and in vitro cell toxicity assays were performed.

Main Results:

  • Sheet and ointment hydrogels released vancomycin at therapeutic concentrations for 6-9 days, with CNPs extending release duration.
  • Fickian diffusion was the dominant release mechanism in sheet hydrogels, with a minor contribution from case II relaxation.
  • Sheet hydrogels showed higher drug release (83.6%) compared to ointments (67.0%), attributed to increased swelling; vancomycin activity was preserved, and hydrogels were non-toxic to fibroblasts and mesenchymal stem cells.

Conclusions:

  • Gellan-based hydrogels can be formulated with tunable mechanical properties for controlled antibiotic delivery in wound healing.
  • The developed hydrogels effectively deliver vancomycin, inhibit bacterial growth in vitro, and are biocompatible.
  • These findings support the potential of gellan-based hydrogels for translation to in vivo wound infection therapies.