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Updated: Feb 27, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

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Published on: October 23, 2015

Smart Polymeric Biomaterials for Clinical Use.

Natalie M Petryk¹, Nghia L B Thai¹, Anita Shukla²

¹Biomedical and Chemical Engineering Department, Syracuse University, Syracuse, New York, USA.

Annual Review of Biomedical Engineering

|February 25, 2026

Summary

This summary is machine-generated.

Stimuli-responsive "smart" biomaterials are revolutionizing medicine by dynamically adapting their structure for enhanced healing. This review covers clinically available and emerging smart materials for diverse biomedical applications.

Keywords:

hydrogel liquid crystal elastomer medical devices shape memory polymer stimuli-responsive

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Published on: August 19, 2015

Area of Science:

Biomaterials Science
Polymer Chemistry
Medical Device Technology

Background:

Biomaterials are evolving from static to dynamic scaffolds that actively promote healing.
Stimuli-responsive (
smart
) biomaterials offer dynamic architectural changes in response to environmental cues.

Purpose of the Study:

To review clinically available smart biomaterials.
To highlight smart biomaterial technologies in clinical trials.
To discuss novel smart materials under development for future clinical use.

Main Methods:

Literature review of smart polymeric biomaterials.
Focus on materials designed for in- or on-body applications.
Analysis of materials responding to endogenous and exogenous signals.

Main Results:

Smart polymeric biomaterials include shape memory polymers, stimuli-responsive hydrogels, and liquid crystal elastomers.
These materials are utilized in embolic devices, orthopedics, drug delivery, and neural scaffolds.
The review categorizes materials by clinical availability: current devices, clinical trials, and future development.

Conclusions:

Smart biomaterials represent a significant advancement in regenerative medicine.
Their ability to respond to various stimuli enables sophisticated biomedical applications.
Continued development promises expanded clinical use in diverse medical fields.