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Updated: Dec 24, 2025
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery
Hongtao Chen1, Shusen You, Qing Cai
1State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, BAIC-SM, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China. zhanglq@mail.buct.edu.cn yinmz@mail.buct.edu.cn.
Abstract:
A fluorescent amino poly(glycidyl methacrylate) (PGOHMA) was synthesized by atom transfer radical polymerization (ATRP) and post-polymerization. The obtained star polymer PGOHMA has eight polymer arms enriched with amine groups for gene delivery. PGOHMA showed much lower cytotoxicity and higher delivery efficiency, compared with the widely used commercial and previously reported gene carriers. Therefore, a new star-shaped fluorescent polymer was successfully synthesized and explored as an efficient gene carrier.
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