Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Differentiation00:57

Cellular Differentiation

4.9K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
4.9K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.2K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.8K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.8K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

2.6K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.6K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.1K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches.

Bioscience reports·2026
Same author

Reverse engineering of BNIP3 identifies a mitochondrial protective peptide.

Nature communications·2026
Same author

AdiY acts as a cytoplasmic pH sensor via histidine protonation to regulate acid stress adaptation in <i>Escherichia coli</i>.

Journal of bacteriology·2025
Same author

The Framework for Genetic Engineering in Desulfovibrionaceae.

ACS synthetic biology·2025
Same author

Pattern formation along signaling gradients driven by active droplet behavior of cell swarms.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Versatile Dual Reporter to Identify Ribosome Pausing Motifs Alleviated by Translation Elongation Factor P.

ACS synthetic biology·2024

Related Experiment Video

Updated: Dec 24, 2025

An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

8.3K

Cell and molecular transitions during efficient dedifferentiation.

John Me Nichols1, Vlatka Antolović1, Jacob D Reich1

  • 1MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, London, United Kingdom.

Elife
|April 8, 2020
PubMed
Summary
This summary is machine-generated.

Dictyostelium cells rapidly dedifferentiate, reversing developmental gene expression. This adaptability allows cells to reach the same outcome via different molecular pathways, crucial for regeneration.

Keywords:
Dictyosteliumbet-hedgingcell plasticitydedifferentiationdevelopmental biologydictyosteliuminduced pluripotent stem cellsregenerative medicinereprogrammingstem cells

More Related Videos

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors
10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

10.8K
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

2.6K

Related Experiment Videos

Last Updated: Dec 24, 2025

An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

8.3K
Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors
10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

10.8K
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

2.6K

Area of Science:

  • Cell biology
  • Developmental biology
  • Molecular biology

Background:

  • Dedifferentiation is a key response to tissue damage but remains poorly understood.
  • Developing Dictyostelium discoideum cells exhibit rapid and efficient dedifferentiation within 24 hours.

Purpose of the Study:

  • Investigate the control mechanisms governing dedifferentiation.
  • Understand the molecular and cellular dynamics of this rapid cellular response.

Main Methods:

  • Utilized single-cell imaging combined with high-temporal-resolution transcriptomics.
  • Analyzed gene expression patterns during the dedifferentiation process in Dictyostelium.

Main Results:

  • Dedifferentiation largely mirrored a reversal of developmental gene expression.
  • Expression changes not following this pattern were linked to ribosome biogenesis.
  • Mutations in early-induced dedifferentiation genes showed minimal impact on developmental reversal.

Conclusions:

  • Cellular adaptability allows for robust dedifferentiation, with flexible temporal ordering of events.
  • Cells converge onto a single expression trajectory despite starting from different fates.
  • These regulatory features likely contribute to effective dedifferentiation during regeneration.