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Updated: Dec 24, 2025
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
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Renal artery stenosis presenting as preeclampsia
Michael Brandon Omar1, William Kogler1, Satish Maharaj2
11Department of Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, USA.
Clinical Hypertension
|April 8, 2020
Summary
Renal artery stenosis can cause severe, difficult-to-treat preeclampsia in pregnant patients. Early diagnosis and revascularization can significantly improve blood pressure control and maternal outcomes.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Obstetrics & Gynecology
Background:
- Renal artery stenosis is a known cause of secondary hypertension.
- In pregnant patients, renovascular hypertension can manifest as new-onset or superimposed preeclampsia, posing significant risks.
Observation:
- A 38-week pregnant patient at 33 weeks gestation presented with severe preeclampsia and refractory hypertension post-delivery.
- Doppler and angiography revealed significant bilateral renal artery stenosis.
Findings:
- Balloon angioplasty and stenting of the left renal artery improved the patient's blood pressure within 48 hours.
- The patient was successfully managed on dual oral antihypertensive therapy post-procedure.
Implications:
- Refractory preeclampsia warrants investigation for underlying renal artery stenosis.
- Doppler ultrasonography is a safe screening tool, followed by angiography if necessary.
- Early revascularization should be considered for severe preeclampsia unresponsive to medical management.
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