Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis

Area of Science:

• Urology
• Oncology
• Pathology

Background:

• Large cell calcifying Sertoli cell tumors (LCCSCTs) are exceptionally rare testicular neoplasms.
• They represent a subtype of Sertoli cell tumors, accounting for a small fraction of testicular tumors globally and in specific regions like Saudi Arabia.
• LCCSCTs typically affect young males and can present multifocally, sometimes associated with microcalcifications.

Observation:

• A 28-year-old male presented with left testicular pain.
• Physical examination revealed no palpable masses, though ultrasonography identified a grade 3 left varicocele and an incidental 9 mm calcified right testicular mass.
• Magnetic Resonance Imaging (MRI) confirmed the calcified testicular lesion.

Findings:

• The patient underwent a partial orchiectomy for the incidentally discovered testicular mass.
• Analysis encompassed clinical data, radiological imaging (ultrasonography, MRI), and detailed morphological and immunohistochemical evaluation.
• Histopathological confirmation of LCCSCT was established.

Implications:

• This case contributes to the limited literature on LCCSCTs, particularly in the context of incidental findings in young adults.
• It underscores the importance of thorough radiological assessment for testicular calcifications, even in the absence of palpable masses.
• Understanding the imaging and pathological features of LCCSCTs aids in accurate diagnosis and appropriate management of these rare tumors.