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DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
Published on: February 1, 2020
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Primary pancreatic lymphoma: Histopathological pattern of 8 cases
1From the Department of Pathology, Faculty of Medicine, King Abdulaziz University; and from the Department of Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia.
Saudi Medical Journal
|March 4, 2024
Summary
Primary pancreatic lymphoma (PPL) is rare, often presenting with abdominal pain. Diffuse large B-cell lymphoma is the most common subtype, necessitating consideration of PPL in pancreatic mass evaluations.
Area of Science:
- Oncology
- Pathology
- Gastroenterology
Background:
- Primary pancreatic lymphoma (PPL) is an exceptionally rare malignancy.
- PPL often lacks specific clinical, laboratory, or radiological indicators, complicating diagnosis.
Purpose of the Study:
- To detail the histopathological characteristics of primary pancreatic lymphoma.
- To review cases from two major tertiary hospitals.
Main Methods:
- Retrospective review of pathology slides and reports from two referral hospitals.
- Immunohistochemistry was employed for lymphoma reclassification according to current standards.
Main Results:
- Eight cases of PPL were identified, with patient ages ranging from 36 to 71 years.
- Common clinical presentations included abdominal pain, weight loss, and jaundice.
- Histopathological analysis revealed diffuse large B-cell lymphoma (5 cases) as the predominant subtype, alongside high-grade B-cell lymphoma, MALT lymphoma, and follicular lymphoma.
Conclusions:
- PPL is a rare entity with non-specific clinical signs, making early diagnosis challenging.
- Diffuse large B-cell lymphoma is the most frequent pathological subtype of PPL.
- Considering PPL in the differential diagnosis of pancreatic masses is crucial to prevent misdiagnosis and unnecessary surgical intervention.
