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Canine congenital diaphragmatic hernia
B A Valentine1, B J Cooper, A E Dietze
1Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Journal of Veterinary Internal Medicine
|July 1, 1988
Summary
Congenital diaphragmatic hernia in puppies suggests autosomal recessive inheritance. This genetic defect, observed in Golden Retrievers from father-daughter matings, indicates a potential hereditary condition in dogs.
Area of Science:
- Veterinary Genetics
- Developmental Biology
- Canine Health
Background:
- Congenital diaphragmatic hernia (CDH) is a serious birth defect.
- Previous reports suggest genetic factors in canine diaphragmatic defects.
Purpose of the Study:
- To investigate the inheritance pattern of congenital diaphragmatic hernia in a canine population.
- To identify the potential mode of inheritance for diaphragmatic defects in puppies.
Main Methods:
- Pedigree analysis of puppies from father-daughter matings.
- Observation of defect occurrence in offspring.
- Correlation with sire lineage (purebred Golden Retriever).
Main Results:
- Five of 27 puppies from three father-daughter matings exhibited CDH.
- The defect was located in the left dorsolateral diaphragm, indicating potential pleuroperitoneal canal closure failure.
- A purebred Golden Retriever was the common sire across affected litters.
Conclusions:
- Findings are consistent with autosomal recessive inheritance of canine diaphragmatic defects.
- This suggests a genetic predisposition that can be passed through generations.
- Further genetic studies are warranted to confirm the mode of inheritance.