Related Experiment Video

Updated: Dec 24, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.8K

The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma

Saranya Chidambaranathan-Reghupaty1, Rachel Mendoza1, Paul B Fisher1,2,3

  • 1Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.

Hepatoma Research
|April 8, 2020
PubMed

Insights

Staphylococcal nuclease and tudor domain containing 1 (SND1) is an oncogene promoting cancer hallmarks. This review focuses on SND1

Area of Science:

  • Oncology
  • Molecular Biology
  • Hepatocellular Carcinoma Research

Background:

  • Staphylococcal nuclease and tudor domain containing 1 (SND1) is a multifunctional protein implicated as an oncogene.
  • SND1 regulates gene expression via transcriptional activation, mRNA degradation, stabilization, ubiquitination, and alternative splicing.
  • Evidence links SND1 to cancer hallmarks including proliferation, invasion, migration, angiogenesis, and metastasis.

Purpose of the Study:

  • To review current knowledge on SND1, particularly its role in hepatocellular carcinoma (HCC).
  • To explore SND1's potential as a therapeutic target for HCC.
  • To highlight SND1's involvement in diverse functions beyond typical oncogenic roles, including lipid metabolism and inflammation, relevant to HCC pathogenesis.

Main Methods:

  • Literature review synthesizing existing research on SND1.
  • Analysis of SND1's molecular functions and oncogenic activities.
  • Focus on SND1's specific implications in hepatocellular carcinoma development and progression.

Main Results:

  • SND1 acts as a promoter of key cancer hallmarks, contributing to tumor growth and spread.
  • SND1's diverse roles in lipid metabolism, inflammation, and stress response are crucial in HCC.
  • SND1's multifaceted functions distinguish it from more narrowly focused oncogenes.

Conclusions:

  • SND1 is a significant oncogene with a broad impact on cancer progression.
  • Understanding SND1's role in HCC, including its links to metabolic and inflammatory pathways, is critical.
  • SND1 presents a promising therapeutic target for hepatocellular carcinoma treatment.
Keywords:
Staphylococcal nuclease and tudor domain containing 1hepatocellular carcinomainflammation

More Related Videos

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.3K
Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

36.9K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.0K