Related Experiment Video
Updated: Dec 24, 2025
Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
Published on: November 21, 2017
Quasi-isothermal modulated DSC as a valuable characterisation method for soft tissue biomaterial crosslinking
K Joyce1,2, S Rahmani2, Y Rochev3,4
1Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences, National University of Ireland Galway (NUIG), Newcastle Road, Galway, Ireland.
Abstract:
Glutaraldehyde (Glut) is an extensively used sterilant and fixative for the crosslinking of natural soft tissue biomaterials like bovine pericardium (BP) to provide stability and is required for its application in vivo. There is plenty of debate around the reaction mechanism of Glut with natural biomaterials. Differential scanning calorimetry (DSC) is a commonly used technique that is typically used to measure the thermal profile of polymers. However, a variation known as quasi-isothermal modulated differential scanning calorimetry (QiMDSC) has been utilised for the analysis of polymorphic transformations in both the pharmaceutical and food industries. This communication will address QiMDSC as a method for analysing soft tissue biomaterials and their crosslinking mechanisms and how it can be applied to other biomaterial applications.
