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Related Experiment Video

Updated: Dec 24, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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Multiple Sclerosis and Smoking.

Borros Arneth1

  • 1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg UKGM, Justus Liebig University Giessen, Giessen, Hessen Germany.

The American Journal of Medicine
|April 8, 2020
PubMed
Summary

Smoking significantly increases the risk of developing multiple sclerosis (MS) and exacerbates its progression. Further research is needed to fully understand the molecular mechanisms linking smoking to MS development and outcomes.

Keywords:
CigarettesDisease activityMultiple sclerosisSmoking

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Area of Science:

  • Neurology
  • Epidemiology
  • Toxicology

Background:

  • Multiple sclerosis (MS) is a prevalent and severe neurological disorder with an unknown etiology.
  • Smoking is a known risk factor for various diseases and has been investigated for its role in MS.

Purpose of the Study:

  • To review the existing literature on the association between smoking and multiple sclerosis (MS).
  • To explore potential molecular mechanisms underlying the link between smoking and MS.
  • To assess the impact of smoking on MS risk and progression.

Main Methods:

  • A literature search was conducted on PubMed for studies published between 2012 and 2020.
  • Keywords included "multiple sclerosis," "smoking," "risk factors," "cigarettes," and "molecular mechanisms."
  • Evidence from randomized controlled trials, systematic reviews, and epidemiological studies was synthesized.

Main Results:

  • A significant relationship exists between smoking and an increased risk of developing MS.
  • Smoking is associated with MS progression at both individual and population levels.
  • Smokers exhibit a higher likelihood of developing MS and experiencing adverse symptoms and complications.

Conclusions:

  • Smoking is a confirmed risk factor for multiple sclerosis.
  • The precise molecular mechanisms require further investigation.
  • Understanding this link is crucial for MS prevention and management strategies.