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Changes in corticotropin releasing factor system transcript levels in relation to feeding condition in Acipenser
Jinwen Qi1, Shaoqi Xu1, Mei Wang1
1Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China.
Peptides
|April 8, 2020
Summary
The CRF system regulates feeding in mammals, but its role in fish is unclear. This study shows CRF system components (UCNs) change with feeding status in Acipenser dabrya, suggesting a role in fish feeding regulation.
Area of Science:
- Comparative physiology
- Endocrinology
- Fish biology
Background:
- The Corticotropin-Releasing Factor (CRF) system is involved in feeding regulation in mammals.
- Physiological mechanisms differ significantly between mammals and teleost fish, leaving the CRF system's role in fish feeding largely unknown.
Purpose of the Study:
- To investigate the potential role of the CRF system in feeding regulation in Acipenser dabryanus.
- To examine the gene expression patterns of CRF system components (Urocortins, CRF-Binding Protein) under varying energy states.
Main Methods:
- Gene expression analysis of Urocortin (UCN) and CRF-Binding Protein (CRF-BP) in Acipenser dabryanus.
- Comparison of gene expression levels after feeding (post-prandial) and fasting (10 days).
Main Results:
- Urocortins (UCNs) mRNA expression increased after feeding.
- Urocortins (UCNs) mRNA expression decreased after 10 days of fasting.
- CRF-Binding Protein (CRF-BP) mRNA abundance showed no significant changes.
Conclusions:
- The study confirms a potential role for the CRF system in regulating feeding behavior in Acipenser dabryanus.
- Gene expression patterns of UCNs correlate with energy status, supporting their involvement in feeding control in this teleost species.
