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Cardiac dynamics.

W W Parmley, J V Tyberg, S A Glantz

    Annual Review of Physiology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This review highlights hemodynamic factors influencing left ventricular pressure-volume relations and the benefits of afterload reduction in heart failure. It also discusses methods for measuring ischemic myocardium, emphasizing ultrasonic crystals for improved accuracy.

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    Area of Science:

    • Cardiovascular Physiology
    • Cardiac Mechanics
    • Myocardial Ischemia Research

    Background:

    • Renewed interest in coronary artery disease and heart failure management.
    • Previous studies focused on mathematical models of left ventricular pressure-volume relations.
    • Limited understanding of hemodynamic influences on diastolic function.

    Purpose of the Study:

    • To review conceptual approaches to left ventricular diastolic pressure-volume relations.
    • To emphasize the role of afterload in cardiac function and heart failure.
    • To discuss methods for measuring regionally ischemic myocardium.

    Main Methods:

    • Conceptual review of hemodynamic factors affecting left ventricular pressure-volume relationships.
    • Analysis of afterload's impact on cardiac function, particularly in heart failure.

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  • Review of techniques for measuring local mechanical performance of ischemic myocardium, including ultrasonic crystals.

    • Main Results:

    • Hemodynamic factors acutely alter the left ventricular pressure-volume relationship.
    • Afterload reduction with vasodilators provides significant hemodynamic benefits in heart failure.
    • Ultrasonic crystals offer improved measurement of myocardial mechanics compared to older methods.

    Conclusions:

    • Hemodynamic factors, including right ventricular pressure, significantly influence left ventricular diastolic function.
    • Afterload reduction is a key therapeutic strategy in heart failure, though optimal measurement remains debated.
    • Accurate assessment of myocardial mechanical performance is crucial for preserving ischemic tissue.