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Updated: Aug 15, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
Published on: April 18, 2011
[Effect of clinostatic and anti-orthostatic hypokinesia on serum enzyme activity]
Abstract:
Seven-day exposure to clinostatic and antiorthostatic hypokinesia led to a significant decrease of Krebs cycle enxymes (malate dehydrogenase--MDH and isocitrate dehydrogenase) and creatine phosphokinase with no significant changes in lactate dehydrogenase (LDH), aspartate aminotransferase, alanine aminotransferase and MDH and LDH isoenzymes. This hypofermentemia returned to normal during 7-day readaptation. It was not associated with hemodynamic changes or emotional stress. The hypofermentemia was adaptive and induced by diminished motor activity.
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