Related Experiment Video
Updated: Dec 24, 2025
10:16
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
7.9K
Dendrimer-based nanodevices for targeted drug delivery applications
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, People's Republic of China.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Dendrimers offer a unique platform for targeted drug delivery, utilizing their structure to carry drugs internally or externally. Their adaptable surfaces allow for precise targeting, especially in cancer therapeutics.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmacology
Background:
- Dendrimers possess unique 3-dimensional architectures and macromolecular characteristics.
- These properties make them suitable for drug delivery applications.
- Their structure allows for drug encapsulation or surface conjugation.
Purpose of the Study:
- To review recent advances in using dendrimers for targeted drug delivery.
- To highlight dendrimers' versatility as a drug delivery platform.
- To detail their application in targeted cancer therapeutics.
Main Methods:
- Review of recent scientific literature on dendrimer applications in drug delivery.
- Analysis of dendrimer properties, including encapsulation and surface functionalization.
- Focus on case studies related to cancer therapeutics.
Main Results:
- Dendrimers can encapsulate drugs within their interior.
- Drugs can be covalently conjugated to dendrimer surfaces.
- Surface functionalization enables the attachment of targeting molecules, creating multifunctional nanodevices.
Conclusions:
- Dendrimers are a versatile platform for targeted drug delivery.
- Their adaptable structure and surface chemistry are key to their efficacy.
- Significant potential exists for dendrimers in targeted cancer therapy.
Related Concept Videos
01:16Drug Delivery: Overview
652
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
652
01:22Drug Delivery: Miscellaneous Routes
669
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
669