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Updated: Dec 24, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Aggregation induced photodynamic therapy enhancement based on linear and nonlinear excited FRET of fluorescent
Meng-Chieh Hsieh1, Cheng-Hao Chien, Cheng-Chung Chang
1Graduate Institute of Biomedical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan, ROC. ccchang555@dragon.nchu.edu.tw.
Abstract:
A binary molecule can self-assemble to form fluorescent organic nanoparticles (FONs) based on the Aggregation-Induced Emission Enhancement (AIEE) property and subsequently, presents an efficient fluorescence resonance energy transfer (FRET) to generate singlet oxygen under linear and nonlinear light sources. Biologically, this FON-photosensitizer is much more phototoxic to cancer cells than to normal cells without significant dark toxicity. Eventually, a new approach, called FON FRET-PDT or AIEE FRET-PDT, to promote the PDT effect is expected.
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