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Related Experiment Video

Updated: Dec 24, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Nanoporous cyclodextrin-based co-polymeric microspheres for encapsulation of active components.

Baghali G Mathapa¹, Vesselin N Paunov

¹Surfactant and Colloid Group, Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK. V.N.Paunov@hull.ac.uk.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

New nanoporous microspheres made from polyallylamine hydrochloride (PAH)-cyclodextrin effectively encapsulate molecules. These versatile microspheres show promise for applications in water purification, drug delivery, and separation science.

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Area of Science:

Materials Science
Polymer Chemistry

Background:

Nanoporous materials offer unique properties for molecular encapsulation.
Polyallylamine hydrochloride (PAH) and cyclodextrin (CD) are versatile polymers with potential for composite materials.

Purpose of the Study:

To fabricate and characterize novel PAH-CD co-polymeric microspheres.
To evaluate the encapsulation and removal capabilities of these microspheres for various molecules.

Main Methods:

Fabrication of microspheres using epichlorohydrin cross-linking.
Characterization via optical microscopy, electron microscopy, and FT-IR spectrometry.
Encapsulation and removal studies using fluorescent dyes and surfactants, analyzed by Laser Scanning Confocal Microscopy (LSM), surface tension measurements, and UV-vis spectroscopy.

Main Results:

Successful synthesis of nanoporous PAH-CD co-polymeric microspheres confirmed by FT-IR.
Demonstrated significant encapsulation of fluorescing dyes within the microspheres.
Effective removal of surfactants (CTAB, SDS) and organic dyes (Indophenol Blue) from aqueous solutions.

Conclusions:

PAH-CD co-polymeric microspheres exhibit excellent molecular encapsulation capabilities for diverse molecules.
These microspheres are promising for applications in water purification, drug delivery, separation science, and cosmetics.