[Dehydrogenase activity of the liver in rats following 30 days' exposure to hypergravity]

In response to 30-day centrifugation at 2.0 or 1.1 G rats showed decreases in liver mitochondrial and cytoplasmic NAD-dependent malate dehydrogenase and NADH-dependent isocitrate dehydrogenase. These changes can be considered as a decline of energetic and biosynthetic processes in the liver in response to hypodynamics and hypergravity. After cessation of centrifugation the liver enzymes returned to the pretest level: cytoplasmatic dehydrogenases on the 2nd day and mitochondrial malate dehydrogenase on the 7th day of recovery.