Related Experiment Video
Updated: Dec 24, 2025
Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Attaching double chain cationic Gd(iii)-containing surfactants on nanosized colloids for highly efficient MRI
Yingying Chen1, Heng Yang, Weijun Tang
1Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China. hagmhsn@ecust.edu.cn.
Abstract:
A new Gd(iii)-based metallosurfactant with double quaternary-ammonium-containing long alkyl chains was developed and subjected to the miniemulsion polymerization of vinyl monomers, giving nanosized colloids (50-110 nm) with narrow size distribution. The size of the colloid particles can be easily tuned by adjusting the feeding ratio of metallosurfactant to monomer. SEM and XPS analysis showed that the Gd(iii) complexes were attached on the surface of the colloids. ICP-AES analysis further quantified the contents of Gd(iii) in the miniemulsions. T1 magnetic resonance imaging (MRI) showed that these Gd(iii)-loading colloids exhibited relaxivity of up to 22.77 mM-1 s-1, much higher than that of Ominiscan® (4.64 mM-1 s-1).
