Related Experiment Video
Updated: Jan 15, 2026
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
Published on: November 9, 2020
A chimeric enediyne for targeted degradation of a tumor-associated protein
Fangxu Pu1, Xuejie Li2,3, Haonan Cheng1
1Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. hagmhsn@ecust.edu.cn.
Abstract:
A protein-radical-oxidation targeting enediyne chimera (PROTEC) comprising an enediyne warhead and a protein-targeting moiety was developed for the selective degradation of a tumor-associated protein. PROTEC operates by forming a binary complex with the protein of interest and inducing oxidative protein degradation by the radical species generated from the cycloaromatization of the enediyne moiety.
More Related Videos
11:02Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
10:44Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
