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Updated: Dec 24, 2025

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
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Chemically regulated bioactive ion delivery platform on a titanium surface for sustained controlled release.

Jinhua Li1, Wenjie Zhang, Yuqin Qiao

  • 1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.

Journal of Materials Chemistry. B
|April 9, 2020
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Summary

Biomedical titanium implants were surface-modified with strontium (Sr2+) and magnesium (Mg2+) ions. This enhanced implant biocompatibility and osteogenic activity, improving potential for bone regeneration.

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Area of Science:

  • Biomaterials Engineering
  • Surface Science
  • Nanotechnology

Background:

  • Biomedical implant efficacy relies heavily on surface properties like morphology, microstructure, and composition.
  • Developing advanced surface modifications is crucial for enhancing implant performance and osseointegration.

Purpose of the Study:

  • To create a hierarchical hybrid micro/nanotip film on titanium surfaces.
  • To incorporate bioactive strontium (Sr2+) and magnesium (Mg2+) ions for sustained release.
  • To evaluate the bioactivity, biocompatibility, and osteogenic potential of the modified surfaces.

Main Methods:

  • Surface modification of titanium using a combination of acid etching and hydrothermal treatment.
  • Incorporation of Sr2+ and Mg2+ ions via an ion exchange process.
  • In vitro studies including Simulated Body Fluid (SBF) tests and cell culture experiments.

Main Results:

  • Successful fabrication of a Sr/Mg ion-releasing platform on titanium surfaces.
  • Demonstrated good bioactivity and controlled ion release in SBF tests.
  • Confirmed enhanced biocompatibility and osteogenic activity in cell experiments.

Conclusions:

  • The developed ion exchange technique offers a facile and versatile method for functionalizing titanium surfaces.
  • The micro/nanostructured titanium surfaces with Sr/Mg ions show promise for improved biomedical implant applications.
  • This strategy provides valuable insights for designing next-generation biomedical implant surfaces.