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Selective biofunctional modification of titanium implants for osteogenic and antibacterial applications
Shi Qian1, Yuqin Qiao, Xuanyong Liu
1State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China. xyliu@mail.sic.ac.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
This study reviews modifications to titanium orthopedic implants to improve bone integration and prevent infection. Strategies like nanostructures and external fields enhance implant bioactivity for better patient outcomes.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Surface Chemistry
Background:
- Orthopedic implants face challenges like bone integration failure and infection.
- Cell-surface interactions are key to developing implants with osteogenic and antibacterial properties.
Purpose of the Study:
- To highlight diverse modifications of titanium orthopedic implants for selective biofunctionalization.
- To summarize recent advances in surface engineering for enhanced implant performance.
Main Methods:
- Review of structural and chemical surface modifications.
- Analysis of organized nanostructures, hybrid structures, inorganic incorporation, and external field assistance (photoirradiation, electrical, electromagnetic).
Main Results:
- Diverse surface modification strategies enhance implant bioactivity.
- Nanostructures, hybrid structures, inorganic components, and external fields show promise.
- Synergetic effects between different strategies are being explored.
Conclusions:
- Surface modifications are crucial for "smart" and "personalized" orthopedic implants.
- Further research into cell-implant interactions and synergetic effects is needed for advanced implant design.
