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Updated: Dec 24, 2025

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Gelation properties of self-assembling N-acyl modified cytidine derivatives
K J Skilling1, A Ndungu, B Kellam
1School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. maria.marlow@nottingham.ac.uk.
Abstract:
In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5% (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers.
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