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Published on: June 14, 2021
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Preparation and application of cyclodextrin immobilized polysaccharides
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, China. jsyang@yzu.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Cyclodextrins immobilized onto polysaccharides create novel materials. These functional macromolecules offer enhanced properties for applications in drug delivery and tissue engineering.
Area of Science:
- Biomaterials Science
- Macromolecular Chemistry
- Nanotechnology
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with hydrophobic cavities capable of forming inclusion complexes.
- Polysaccharides are biocompatible, non-toxic, and biodegradable natural polymers.
- Combining CDs with polysaccharides yields novel functional macromolecules with unique properties.
Purpose of the Study:
- To review methods for immobilizing cyclodextrins onto polysaccharides.
- To discuss the properties of these CD-immobilized polysaccharide derivatives.
- To explore their potential applications in various fields.
Main Methods:
- Review of literature on cyclodextrin immobilization techniques.
- Analysis of the physicochemical properties of resulting conjugates.
- Exploration of reported applications in drug delivery, tissue engineering, and separation.
Main Results:
- Various methods exist for immobilizing CDs onto polysaccharides.
- CD-immobilized polysaccharides exhibit combined properties of both components, including inclusion complexation, size specificity, controlled release, and biocompatibility.
- Nanoscale associations can form particles and films.
Conclusions:
- Cyclodextrin-immobilized polysaccharides represent a promising class of functional biomaterials.
- Their unique properties enable diverse applications, particularly in advanced drug delivery systems and tissue engineering scaffolds.
- Further research into immobilization methods and applications is warranted.
