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Modular composite hydrogels from cholesterol-functionalized polycarbonates for antimicrobial applications.

Ashlynn L Z Lee1, Shrinivas Venkataraman, Courtney H Fox

  • 1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore. yyyang@ibn.a-star.edu.sg.

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Researchers developed injectable hydrogels that combine drug delivery micelles with supramolecular assemblies. These tunable micellar composite hydrogels show promise for delivering hydrophobic drugs and possess antimicrobial properties.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Micellar composite hydrogels offer potential for biomolecule and drug delivery.
  • Developing injectable, viscoelastic materials is a key goal in advanced therapeutics.

Purpose of the Study:

  • To create novel shear-thinning, injectable micellar composite hydrogels.
  • To integrate drug-loaded micelles into a tunable hydrogel system.
  • To impart antimicrobial activity and anionic drug delivery capabilities.

Main Methods:

  • Synthesized amphiphilic ABA-type triblock copolymers with cholesterol-functionalized hydrophobic blocks.
  • Formulated micellar composite hydrogels by varying copolymer concentration and composition.
  • Encapsulated drug-loaded polymeric micelles within the hydrogel matrix.
  • Characterized hydrogel properties using rheology, small-angle X-ray scattering (SAXS), and electron microscopy (EM).

Main Results:

  • Tunable storage moduli ranging from 200 Pa to 3500 Pa were achieved.
  • Hydrogels demonstrated successful encapsulation and sustained release of Amphotericin B (AmB).
  • Antimicrobial composites showed significant efficacy against bacteria and fungi.
  • SAXS and EM provided insights into the self-assembly and mesoscale structure.

Conclusions:

  • Developed a modular system for creating injectable micellar composite hydrogels.
  • Demonstrated the potential for delivering hydrophobic drugs and charged macromolecules.
  • Highlighted the antimicrobial and antifungal efficacy of the developed materials.
  • The system shows promise for diverse pharmaceutical applications.