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Related Experiment Video

Updated: Dec 24, 2025

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Multifunctionalized polyurethane-polyurea nanoparticles: hydrophobically driven self-stratification at the o/w

Pau Rocas1, Yolanda Fernández, Simó Schwartz

  • 1Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028 Barcelona, Spain. pau.rocas@irbbarcelona.org.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
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Researchers developed novel multiwalled polyurethane-polyurea nanoparticles for enhanced drug delivery. These nanoparticles offer improved stability and targeted release, showing promise for cancer therapy applications.

Area of Science:

  • Polymer Chemistry
  • Nanotechnology
  • Biomaterials Science

Background:

  • Developing stable nanocarriers for lipophilic compounds is challenging.
  • Existing nanostructures often lack controlled release and targeted delivery capabilities.
  • Multiwalled nanostructures offer potential for enhanced functionality.

Purpose of the Study:

  • To synthesize and characterize novel multiwalled polyurethane-polyurea (PUUa) nanoparticles.
  • To investigate the enhanced encapsulation stability of these nanostructures for lipophilic compounds.
  • To demonstrate targeted delivery and controlled release functionalities for potential therapeutic applications.

Main Methods:

  • Synthesis of PUUa reactive prepolymers with tailored hydrophobic and hydrophilic chains.

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  • Formation of multiwalled nanoparticles via interfacial self-assembly.
  • Functionalization with disulfide bonds and cyclic RGD peptide (cRGDfK).
  • Evaluation of encapsulation stability and in vitro cell targeting with U87 tumor cells.

    • Main Results:

    • Successfully created sub-30 nm multiwalled PUUa nanoparticles with stratified shells.
    • Demonstrated superior encapsulation stability for lipophilic compounds compared to monowalled systems.
    • Achieved glutathione (GSH)-triggered controlled release and specific targeting of U87 tumor cells via cRGDfK functionalization.

    Conclusions:

    • Multiwalled PUUa nanoparticles represent a promising platform for enhanced drug delivery.
    • The stratified shell structure improves lipophilic compound encapsulation and stability.
    • Engineered nanoparticles exhibit controlled release and targeted cell specificity, paving the way for advanced nanomedicine.