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Published on: June 23, 2020
A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance
Juan Liu1, Xiaowei Ma, Chunni Lei
1CAS Center for Excellence in Nanoscience, Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and Laboratory of Controllable Nanopharmaceuticals, National Center for Nanoscience and Technology, Beijing 100190, China. liangxj@nanoctr.cn.
Abstract:
We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The resulting nanostructure was able to specifically target cancer cells and release the loaded drug at pH 5.0. More importantly, the drug-loaded DNA nanostructure effectively circumvented doxorubicin resistance of human lung adenocarcinoma epithelial cancer cells.
