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Layered MoS2 nanoflowers for microwave thermal therapy
Shengping Wang1, Longfei Tan, Ping Liang
1Department of Materials Science and Engineering, Jinan University, Guangzhou, 510632, P. R. China. tlihong@jnu.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Layered molybdenum disulfide (MoS2) nanoflowers coated with bovine serum albumin (BSA-MoS2) show promise for green cancer therapy. These agents effectively eliminate tumors using microwave hyperthermia with low toxicity.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Microwave (MW) hyperthermia is an emerging green tumor thermotherapy.
- Developing efficient and safe microwave-susceptible agents is crucial for effective cancer treatment.
Purpose of the Study:
- To synthesize layered MoS2 nanoflowers for MW hyperthermia.
- To evaluate the in vitro and in vivo efficacy of BSA-MoS2 as a cancer therapeutic agent.
Main Methods:
- Layered MoS2 nanoflowers were prepared via a hydrothermal process.
- MoS2 nanoflowers were coated with bovine serum albumin (BSA-MoS2).
- In vitro biotoxicity and microwave-susceptive properties were assessed. Computer simulations confirmed the heating effect of the layered structure. In vivo cancer therapy was conducted using MW irradiation.
Main Results:
- BSA-MoS2 exhibited low biotoxicity and excellent microwave-susceptive properties in vitro.
- The layered structure of MoS2 enhanced the heating effect, confirmed by simulations.
- Layered BSA-MoS2 nanoflowers achieved 100% tumor elimination in vivo via MW hyperthermia.
Conclusions:
- Layered BSA-MoS2 nanoflowers are effective and safe agents for microwave hyperthermia cancer therapy.
- This approach offers a promising green thermotherapy strategy for cancer treatment.
