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Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications
Xiaoman Li1, Bing Han, Xiaoyan Wang
1Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China. wangxiaoyan@pkuss.bjmu.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
New chitosan-ethylcellulose coated calcium hydroxide microcapsules offer improved biocompatibility and controlled drug release for apical periodontitis (AP) treatment. These microcapsules show pH-triggered release, enhanced antibacterial action, and promote bone healing.
Area of Science:
- Biomaterials Science
- Endodontics
- Drug Delivery Systems
Background:
- Apical periodontitis (AP) treatment is challenging due to complex root canal anatomy, drug limitations, and host factors.
- Developing biocompatible, controlled drug release systems is crucial for effective AP therapy.
- Traditional root canal therapy (RCT) has limitations in achieving optimal outcomes.
Purpose of the Study:
- To prepare and characterize chitosan and ethylcellulose coated calcium hydroxide microcapsules (CS-EC@Ca(OH)2) for AP treatment.
- To evaluate the controlled-release properties, biocompatibility, and therapeutic potential of the developed microcapsules.
- To investigate the pH-triggered drug release, antibacterial activity, and effects on inflammation and osteogenesis.
Main Methods:
- Preparation of CS-EC@Ca(OH)2 microcapsules.
- Fourier-transform infrared spectroscopy (FT-IR) to confirm hydrogen bonding in shell materials.
- In vitro release studies in buffers of different pH (5.0 and 7.0).
- Biological assays to assess antibacterial activity against Enterococcus faecalis, anti-inflammatory effects, and osteogenic potential.
Main Results:
- CS-EC@Ca(OH)2 microcapsules demonstrated enhanced controlled-release performance and biocompatibility.
- Drug release was significantly pH-triggered, with 8-fold higher cumulative release at pH 5.0 compared to pH 7.0.
- Microcapsules exhibited prolonged antibacterial activity against resistant Enterococcus faecalis strains.
- CS-EC@Ca(OH)2 microcapsules showed reduced inflammation and promoted osteogenesis in vitro.
Conclusions:
- CS-EC@Ca(OH)2 microcapsules effectively improve the properties of calcium hydroxide for AP treatment.
- The pH-triggered release mechanism and enhanced biocompatibility offer a promising approach for managing AP.
- These microcapsules hold significant potential for clinical application in treating apical periodontitis and associated bone defects.
