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Updated: Dec 24, 2025
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Nanodiamond-PMO for two-photon PDT and drug delivery
Chiara Mauriello Jimenez1, Nikola Z Knezevic, Yolanda Galàn Rubio
1Institut Charles Gerhardt Montpellier, UMR 5253, CC 1701 Equipe Ingénierie Moléculaire et Nano-objets, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. durand@um2.fr.
Abstract:
In this article, we highlight the properties of nanodiamonds (ND), which were encapsulated in periodic mesoporous organosilica nanoparticles (PMO) and were able to generate reactive oxygen species for photodynamic applications upon two-photon excitation (TPE). The ND@PMO nanoparticles were characterized by various techniques and were then loaded with the anti-cancer drug doxorubicin. The release of the drug was pH sensitive and a synergistic cancer cell killing effect was observed when cancer cells were incubated with doxorubicin-loaded ND@PMO and irradiated with two-photon excitation at 800 nm.
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