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Related Experiment Video

Updated: Dec 24, 2025

Generation of Alginate Microspheres for Biomedical Applications
10:33

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Published on: August 12, 2012

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Core-shell alginate@silica microparticles encapsulating probiotics.

F B Haffner1, M Girardon, S Fontanay

  • 1CNRS, Structure et Réactivité des Systèmes Moléculaires Complexes, SRSMC, UMR 7565, Nancy, France.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary
This summary is machine-generated.

We developed novel alginate-silica microcapsules for encapsulating Lactobacillus rhamnosus GG (LGG). These microcapsules enable controlled bacterial growth and offer potential for effective oral probiotic delivery.

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Area of Science:

  • Biomaterials Engineering
  • Microbiology
  • Drug Delivery Systems

Background:

  • Probiotic viability and delivery are often limited by gastrointestinal conditions.
  • Encapsulation technologies are crucial for protecting and delivering live microorganisms.

Purpose of the Study:

  • To develop core-shell alginate-silica microcapsules for encapsulating Lactobacillus rhamnosus GG (LGG).
  • To investigate the influence of mineralization conditions on LGG viability within the microcapsules.
  • To demonstrate controlled bacterial proliferation within the microcapsules for potential oral delivery applications.

Main Methods:

  • Electrospraying of ionogel for core formation.
  • Coating with a silica shell via alkoxysilane precursor hydrolysis and condensation.
  • Optimization of mineralization conditions (aqueous vs. organic phases).
  • Assessment of LGG viability and proliferation within microcapsules.

Main Results:

  • Successful encapsulation of LGG in core-shell alginate-silica microcapsules.
  • Mineralization conditions critically impact LGG viability.
  • Silica shell's non-swelling and mesoporosity prevented cell leakage.
  • Enabled controlled bacterial growth within the microcapsules.

Conclusions:

  • Proof-of-concept for controlled bacterial proliferation in microcompartments.
  • Alginate-silica microcapsules provide a protective environment for probiotics.
  • Demonstrated potential for enhanced oral delivery of probiotics.