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Updated: Dec 24, 2025
Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
Published on: January 18, 2020
Promoting neural differentiation of embryonic stem cells using β-cyclodextrin sulfonate
Zhonglin Lyu1, Xiujuan Shi, Jiehua Lei
1State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. yuqian@suda.edu.cn chenh@suda.edu.cn.
Abstract:
A heparin-mimicking biomolecule, β-cyclodextrin decorated with sulfonate groups (CD-S), was synthesized. CD-S itself exhibited bioactivity similar to that of heparin and can further serve as a carrier for all-trans retinoic acid by forming inclusion complexes that promote neural differentiation of embryonic stem cells more effectively than heparin.
