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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

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Thermo-responsive polymers and their application as smart biomaterials.

Young-Jin Kim¹, Yukiko T Matsunaga

¹Center for International Research on Integrative Biomedical Systems (CIBiS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan. mat@iis.u-tokyo.ac.jp.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

This review explores smart thermo-responsive polymers, which are intelligent biomaterials that change properties in response to temperature. These advanced polymers offer potential for novel smart biomaterial applications.

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Area of Science:

Polymer Science
Biomaterials Engineering
Materials Science

Background:

Polymeric materials have seen significant development for biomedical applications.
A new class of 'smart' or 'intelligent' biomaterials has emerged, exhibiting responsiveness to environmental changes.
These smart materials possess dynamically alterable properties, enabling the creation of advanced smart biomaterials.

Purpose of the Study:

To review smart thermo-responsive polymers.
To discuss their potential use as smart biomaterials.
To introduce various forms and applications of these smart biomaterials.

Main Methods:

Description of typical thermo-responsive polymers (lower critical solution temperature-type, upper critical solution temperature-type, thermo-induced shape-memory polymers).
Explanation of the basic mechanisms underlying thermo-response processes.
Introduction to applications of smart biomaterials in various forms (fibers, surfaces, hydrogels).

Main Results:

Smart thermo-responsive polymers exhibit distinct temperature-dependent behaviors.
Understanding thermo-response mechanisms is crucial for material design.
Diverse applications are emerging for smart biomaterials in different physical forms.

Conclusions:

Smart thermo-responsive polymers represent a significant advancement in biomaterials.
Their unique properties allow for tailored responses in biomedical applications.
Further exploration of smart biomaterials in various forms like fibers, surfaces, and hydrogels is warranted.