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Via precise interface engineering towards bioinspired composites with improved 3D printing processability and

Felix Hanßke1, Onur Bas, Cédryck Vaquette

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Interface engineering using peptide-polymer conjugates significantly improved the mechanical properties and toughness of biodegradable composites. This advancement is crucial for load-bearing applications in bone tissue engineering, enhancing material performance and durability.

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Nanotechnology

Background:

  • Biodegradable composites are essential for load-bearing applications in bone tissue engineering.
  • Improving the mechanical properties, such as elastic moduli and toughness, is critical for their clinical success.
  • Inorganic-organic hybrid materials offer potential but often face challenges with filler-matrix compatibility.

Purpose of the Study:

  • To investigate the use of peptide-polymer conjugates as precision compatibilizers for inorganic-organic hybrid materials.
  • To enhance the mechanical properties and toughness of biodegradable composites for bone tissue engineering applications.
  • To evaluate the impact of compatibilization on scaffold performance, including mechanical properties, degradation, ion release, and cell viability.

Main Methods:

  • Synthesis of MgF2-binding peptide-polymer conjugates (MBC).
  • Preparation of MBC-compatibilized magnesium fluoride nanoparticles (cMgF2) and poly(ε-caprolactone) composites.
  • Additive biomanufacturing of scaffolds from composite materials.
  • Mechanical testing (tensile, compression, indentation) of filaments and scaffolds.
  • Assessment of degradation behavior, ion release kinetics, and in vitro cell viability.

Main Results:

  • MBC compatibilizers effectively stabilized MgF2 nanoparticles and improved interactions with the polymer matrix.
  • The presence of cMgF2 significantly enhanced elastic moduli and material toughness compared to non-compatibilized MgF2 (pMgF2).
  • Improved mechanical properties, degradation profiles, ion release kinetics, and in vitro cell viability were observed with compatibilized nanoparticles.

Conclusions:

  • Precise interface engineering using MBC significantly enhances the mechanical performance of biodegradable composites.
  • The developed compatibilization strategy is highly relevant for load-bearing applications in bone tissue engineering.
  • The study demonstrates a viable approach to creating advanced biomaterials with superior mechanical and biological properties.