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Bioactive glasses in wound healing: hope or hype?
Shiva Naseri1, William C Lepry, Showan N Nazhat
1Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada. showan.nazhat@mcgill.ca.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Bioactive glasses show promise for wound healing by releasing ions that stimulate tissue repair. Further research is needed to fully understand their mechanisms in accelerating healing processes.
Area of Science:
- Biomaterials science
- Regenerative medicine
- Tissue engineering
Background:
- Bioactive glasses (BGs) are traditionally used for mineralized tissue regeneration.
- Recent studies highlight BGs' potential in soft tissue repair, particularly wound healing.
- Specific formulations like Bioglass® 45S5 and 13-93B3 have shown promise.
Purpose of the Study:
- To review bioactive glass formulations investigated for wound healing.
- To summarize the mechanisms by which BGs may accelerate wound healing.
- To provide an overview of wound healing stages.
Main Methods:
- Literature review of bioactive glasses in wound healing.
- Analysis of ion release from BGs and their biological effects.
- Synthesis of current understanding on BG mechanisms in wound repair.
Main Results:
- BGs release ions that stimulate key wound healing processes: hemostasis, antibacterial activity, cell migration, angiogenesis, and proliferation.
- A borate-based glass wound dressing has received regulatory approval.
- Comprehensive reports on specific mechanisms of action are still lacking.
Conclusions:
- Bioactive glasses offer a promising therapeutic strategy for wound healing.
- Understanding the ion-releasing mechanisms is crucial for optimizing BG applications.
- Further research is warranted to elucidate the precise molecular pathways involved.
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