Overcoming multidrug resistance through co-delivery of ROS-generating nano-machinery in cancer therapeutics
Ranjith Kumar Kankala1, Pei-Yu Tsai, Yaswanth Kuthati
1Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 974, Taiwan. chlee016@gms.ndhu.edu.tw.
Abstract:
The use of nanotechnology to overcome multidrug resistance (MDR) in cancer cells has been predominant. Herein, we report the conjugation of copper(ii)-doxorubicin complexes on the surfaces of layered double hydroxide nanoparticles (LDHs) along with ascorbic acid intercalation in the gallery space to demonstrate synergistic effects to conquer MDR. The pH-sensitive release of doxorubicin (Dox) and the sustained release of ascorbic acid (AA) generate high amounts of hydrogen peroxide intracellularly that concomitantly results in conversion to cytotoxic free radicals through a copper(ii)-catalyzed Fenton-like reaction. Therefore, the combination of the chemotherapeutic agent (Dox) and free radical attack can devastate the MDR for effective cancer treatment through the co-delivery system.
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