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DSA-guided percutaneous sclerotherapy for children with oropharyngeal low-flow venous malformation
Dan Song1,2, Lei Guo2, Hui Sheng3
1Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Insights
Pingyangmycin and dexamethasone combination therapy is a safe and effective treatment for pediatric oropharyngeal low-flow venous malformations, showing comparable efficacy to polidocanol foam but with fewer adverse events.
Area of Science:
- Vascular Surgery
- Pediatric Otolaryngology
- Interventional Radiology
Background:
- Oropharyngeal low-flow venous malformations present unique challenges in pediatric treatment.
- Minimally invasive sclerotherapy is a common approach for venous malformations.
Purpose of the Study:
- To compare the efficacy and safety of digital subtraction angiography-guided polidocanol foam versus a combination of pingyangmycin and dexamethasone for treating pediatric oropharyngeal low-flow venous malformations.
Main Methods:
- A randomized controlled trial involving 27 children with 35 oropharyngeal low-flow venous malformations.
- Group A (16 lesions) received 3% polidocanol foam sclerotherapy.
- Group B (19 lesions) received pingyangmycin and dexamethasone combination therapy.
Main Results:
- Both treatments demonstrated high efficacy rates (Group A: 87.50%, Group B: 84.21%) with no significant difference.
- Average treatment sessions were similar between groups (Group A: 2.45, Group B: 2.07).
- Group B exhibited a significantly lower incidence of adverse reactions (14.29%) compared to Group A (38.46%).
Conclusions:
- The combination of pingyangmycin and dexamethasone is a safe and effective treatment for pediatric oropharyngeal low-flow venous malformations.
- This combination therapy offers a favorable safety profile with fewer adverse reactions.
- Pingyangmycin and dexamethasone warrant further clinical promotion for this condition.
Abstract:
The present study investigated the efficacy and safety of digital subtraction angiography-guided 3% polidocanol foam sclerosing agent, as well as the combination of pingyangmycin and dexamethasone, for the treatment of children with oropharyngeal low-flow venous malformation. A total of 27 children with 35 lesions with oropharyngeal low-flow venous malformation were included. The subjects were randomly divided into Groups A (13 patients with 16 lesions, treated with 3% polidocanol foam sclerosing agent) and B (14 patients with 19 lesions, treated with pingyangmycin + dexamethasone), respectively. The clinical efficacies and adverse reactions were analyzed and compared between these two groups. The average number of treatment times for Group A was 2.45±0.6, with an efficacy rate of 87.50%, while the average number of treatment times for Group B was 2.07±0.4, with an efficacy rate of 84.21%. No significant difference was found in the average treatment times or efficacy rates between Groups A and B. In addition, the adverse reaction incidence for Groups A and B were 38.46 and 14.29%, respectively, with statistically significant differences between these two groups. The combination of pingyangmycin and dexamethasone was safe and effective in treating children with oropharyngeal low-flow venous malformation, with fewer adverse reactions and is worthy of clinical promotion.
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