Cardiometabolic Risk Factors in Pregnancy and Implications for Long-Term Health: Identifying the Research Priorities

Shobhana Nagraj1,2, Stephen H Kennedy1, Robyn Norton2,3

  • 1Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom.

Insights

Cardiometabolic disorders (CMDs) disproportionately affect women in low-resource settings. Early identification and postpartum follow-up of high-risk pregnancies can help prevent or delay CMDs.

Area of Science:

  • Global Health
  • Cardiology
  • Obstetrics & Gynecology

Background:

  • Cardiometabolic disorders (CMDs) are leading causes of death and illness in women globally.
  • These disorders disproportionately impact low and middle-income countries (LMICs), presenting earlier and with higher fatality rates.
  • Pregnancy complications like hypertensive disorders of pregnancy (HDPs) and gestational diabetes mellitus (GDM) signal increased future CMD risk.

Purpose of the Study:

  • To review challenges in identifying and managing pregnant women at risk for CMDs in low-resource settings.
  • To present evidence-based strategies, including novel diagnostics and technologies, for early detection and management.
  • To highlight research priorities for addressing cardiometabolic risk during pregnancy in LMICs.

Main Methods:

  • Mini-review of existing literature and evidence-based strategies.
  • Focus on challenges in early identification, referral, and management.
  • Exploration of novel diagnostics, technology, and innovations.

Main Results:

  • Significant challenges exist in the early identification, referral, and management of pregnant women at risk for CMDs in LMICs.
  • Evidence-based strategies and innovations are available for early detection and management.
  • Key research priorities have been identified to address cardiometabolic risk in pregnancy.

Conclusions:

  • Early identification and postpartum follow-up of women with pregnancy complications are crucial for CMD prevention or delay.
  • Implementing innovative strategies and addressing research priorities are essential for improving outcomes in low-resource settings.
  • Targeting cardiometabolic risk in pregnancy offers a vital window for intervention and long-term women's health improvement.

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