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Related Experiment Video

Updated: Dec 24, 2025

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Ocular Findings Associated with Hypoparathyroidism.

Nurdan Gamze Taşlı1, Emin Murat Akbaş2

  • 1Department of Ophthalmology, College of Medicine, Erzincan Binali Yıldırım University Hospital, Erzincan, Turkey.

Ocular Immunology and Inflammation
|April 9, 2020
PubMed
Summary

Hypoparathyroidism is linked to thinner corneas and retinal nerve fiber layers, along with deeper anterior chamber depth. These ocular changes correlate with serum calcium levels in patients with this endocrine disorder.

Keywords:
Hypoparathyroidismcataractocular findingsretinal nerve fiber layervitamin D

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Biochemistry

Background:

  • Hypoparathyroidism is a rare endocrine disorder characterized by insufficient parathyroid hormone (PTH) production.
  • PTH plays a crucial role in regulating calcium and phosphorus levels in the body.
  • Alterations in calcium and phosphorus metabolism can potentially affect various organ systems, including the eyes.

Purpose of the Study:

  • To investigate the association between serum calcium, phosphorus, and parathyroid hormone (PTH) levels and ocular changes in patients with hypoparathyroidism.
  • To evaluate corneal and retinal parameters in individuals diagnosed with hypoparathyroidism.

Main Methods:

  • A cohort of 75 patients was studied, comprising 35 individuals with hypoparathyroidism and 40 healthy controls.
  • Comprehensive ophthalmological examinations were performed, including measurements of central corneal thickness (CCT) and anterior chamber depth (ACD).
  • Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thicknesses were assessed, alongside recording of serum biochemical parameters.

Main Results:

  • Patients with hypoparathyroidism exhibited significantly thinner central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) compared to healthy controls.
  • A statistically significant deeper anterior chamber depth (ACD) was observed in the hypoparathyroidism group.
  • These ocular findings were found to be related to serum calcium levels.

Conclusions:

  • Hypoparathyroidism is associated with distinct corneal and retinal structural changes, including reduced CCT and RNFL thickness.
  • The observed ocular alterations, specifically thinner CCT and RNFL and deeper ACD, are linked to the underlying hypocalcemia in hypoparathyroidism.
  • Further research is warranted to elucidate the precise mechanisms and long-term implications of these findings.