Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A rat model study.

Area of Science:

• Neuroscience
• Pharmacology
• Toxicology

Background:

• Cisplatin chemotherapy can cause significant neurotoxicity, particularly affecting the optic nerve.
• Oxidative stress and inflammation are key mechanisms underlying cisplatin-induced optic nerve damage.
• Resveratrol, a natural polyphenol, possesses known antioxidant and anti-inflammatory properties.

Purpose of the Study:

• To evaluate the neuroprotective potential of resveratrol against cisplatin-induced optic nerve toxicity in a rat model.
• To assess the impact of resveratrol on oxidative stress markers, inflammation, and histological changes in the optic nerve.

Main Methods:

• Thirty-six Wistar rats were divided into control, cisplatin-only, and cisplatin + resveratrol groups.
• Cisplatin-induced optic nerve damage was established, and resveratrol (25 mg/kg) was administered.
• Levels of malondialdehyde, glutathione, total oxidant status, total antioxidant status, TNF-α, and NF-κB were measured.
• Histopathological examination of optic nerve tissues was performed.

Main Results:

• Resveratrol administration significantly reduced malondialdehyde, total oxidant status, TNF-α, and NF-κB levels compared to cisplatin alone.
• Total glutathione and total antioxidant status levels were significantly increased in the resveratrol-treated group.
• Histological analysis revealed that resveratrol mitigated cisplatin-induced vascular congestion, edema, and cellular degeneration in the optic nerve.

Conclusions:

• Resveratrol exhibits significant antioxidant and anti-inflammatory effects, protecting against cisplatin-induced optic nerve toxicity.
• Resveratrol is a potential neuroprotective agent for managing chemotherapy-induced optic nerve damage.
• Further research is warranted to explore resveratrol's therapeutic efficacy in other forms of optic nerve toxicity.