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Related Experiment Video

Updated: Dec 24, 2025

A Protocol for Real-time 3D Single Particle Tracking

A Protocol for Real-time 3D Single Particle Tracking

Published on: January 3, 2018

3D deterministic lateral displacement (3D-DLD) cartridge system for high throughput particle sorting.

Petra Jusková¹, Lionel Matthys, Jean-Louis Viovy

¹Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005, Paris, France.

Chemical Communications (Cambridge, England)

|April 9, 2020

Summary

A novel 3D deterministic lateral displacement (DLD) microfluidic device architecture using arch-shaped pillars is introduced. This design overcomes the flow rate and shear rate limitations found in traditional planar DLD systems.

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Area of Science:

Microfluidics
Biotechnology
Nanotechnology

Background:

Standard planar deterministic lateral displacement (DLD) devices face limitations in flow rate and shear rate.
These limitations hinder the efficiency and applicability of DLD technology in various applications.

Purpose of the Study:

To present a novel 3D microfluidic device architecture for deterministic lateral displacement (DLD).
To overcome the inherent flow rate and shear rate limitations of conventional planar DLD systems.

Main Methods:

Development of a new 3D architecture for DLD microfluidic devices.
Utilizing ultra-high aspect ratio arch-shaped pillars as the core structural element.

Main Results:

The proposed 3D DLD architecture demonstrates significantly improved flow rate capabilities.
The design effectively mitigates high shear rate issues prevalent in standard devices.
Successful implementation of arch-shaped pillars enables enhanced particle manipulation.

Conclusions:

The novel 3D DLD architecture offers a promising solution for high-throughput and gentle particle separation.
This advancement expands the potential applications of DLD technology in fields requiring precise microfluidic control.