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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
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Circulating endothelial cell derived microvesicles are elevated with hypertension and associated with endothelial

Kelly A Stockelman1, Jamie G Hijmans1, Tyler D Bammert1

  • 1Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.

Canadian Journal of Physiology and Pharmacology
|April 9, 2020
PubMed
Summary

Hypertension is linked to higher levels of circulating endothelial microvesicles (EMVs), which are associated with impaired blood vessel function. These EMVs may indicate or contribute to endothelial dysfunction in hypertensive individuals.

Keywords:
endothelial functionfonction endothélialehypertensionmicrovesiclesmicrovésiculesvasodilatationvasodilation

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Area of Science:

  • Cardiovascular Science
  • Endothelial Biology
  • Hypertension Research

Background:

  • Endothelial microvesicles (EMVs) are cell fragments released from the endothelium.
  • Endothelial dysfunction is a key feature of hypertension.
  • The role of EMVs in hypertension-related endothelial dysfunction requires further investigation.

Purpose of the Study:

  • To determine if circulating EMVs are elevated in hypertensive adults.
  • To assess the association between circulating EMVs and hypertension-related endothelial vasodilator dysfunction.

Main Methods:

  • Quantified circulating EMVs (CD31+/42b-) in 15 normotensive and 15 hypertensive middle-aged adults.
  • Assessed forearm blood flow (FBF) response to acetylcholine and sodium nitroprusside via intra-arterial infusion and plethysmography.

Main Results:

  • Circulating EMVs were approximately 65% higher in hypertensive adults compared to normotensive adults (P < 0.05).
  • Hypertensive individuals exhibited significantly lower FBF response to acetylcholine (impaired vasodilation).
  • Circulating EMVs showed an inverse association with vasodilation (r = -0.65, P < 0.05).

Conclusions:

  • Hypertension is associated with elevated circulating levels of EMVs.
  • EMVs may serve as a biomarker for hypertension-related endothelial dysfunction.
  • Elevated EMVs might contribute to the development of endothelial dysfunction in hypertension.