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Application of allyloxycarbonyl group as a protecting group to oligodeoxyribonucleotide synthesis
Y Mitsuhira1, S Tahara, K Goto
1Biological Science Institute, Nippon Zeon Co. Ltd., Kanagawa, Japan.
Nucleic Acids Symposium Series
|January 1, 1988
Abstract:
The allyloxycarbonyl (AOC) group, known as an efficient amino protective group in solution-phase synthesis of nucleotides, has been used for the first time in solid-phase oligonucleotide synthesis. The efficiency of the new procedure is compared with that of the conventional N-acyl protection.