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STOCHASTIC DYNAMICS OF CELL LINEAGE IN TISSUE HOMEOSTASIS.

Yuchi Qiu1, Weitao Chen2, Qing Nie3

  • 1Department of Mathematics, University of California, Irvine Irvine, CA 92697, USA.

Discrete and Continuous Dynamical Systems. Series B
|April 10, 2020
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Summary
This summary is machine-generated.

Stochastic effects significantly impact tissue maintenance. Cell-intrinsic noise reduces layer size, while cell-extrinsic noise can cause uncontrolled growth, affecting tissue layer thickness and stratification.

Keywords:
Stem cellfeedbackmorphogennoisetissue size

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Area of Science:

  • Developmental Biology
  • Mathematical Biology
  • Tissue Engineering

Background:

  • Epithelium tissue maintenance relies on coordinated cell differentiation and proliferation.
  • Deterministic models analyze feedback in tissue size and stratification, but stochastic effects remain understudied.

Purpose of the Study:

  • To investigate the influence of stochastic effects on tissue layer thickness and stratification.
  • To model cell lineage dynamics under different noise conditions.

Main Methods:

  • Development of a stochastic continuum model for cell lineages.
  • Analysis of cell-intrinsic, cell-extrinsic, and morphogen noise impacts.

Main Results:

  • Cell-intrinsic noise reduces and oscillates layer size; cell-extrinsic noise increases thickness and can cause overgrowth.
  • Increased noise levels generally degrade layer stratification.
  • Morphogen noise can increase layer size with minimal impact on stratification.

Conclusions:

  • Robust tissue homeostasis requires balanced noise levels.
  • A trade-off exists between low thickness variability and strong layer stratification.
  • Noise type and level critically influence tissue layer size, thickness, and stratification.