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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Dec 24, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Astrocytogenesis: where, when, and how.

Ekin Su Akdemir^1,2, Anna Yu-Szu Huang^1,2, Benjamin Deneen^1,2,3,4

¹Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, 77030, USA.

|April 10, 2020

Summary

This summary is machine-generated.

Astrocytes, crucial for brain function, have complex developmental paths. This review explores astrocyte development, current knowledge gaps, and emerging technologies to advance understanding of these vital glial cells.

Keywords:

Astrocyte Glia Gliogenesis Neurodevelopment

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Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

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Published on: August 12, 2014

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Astrocytes are the most prevalent glial cells in the central nervous system.
They play critical roles in maintaining the blood-brain barrier, regulating neural circuits, and metabolic support.
Understanding astrocyte development is key to comprehending brain development and function.

Purpose of the Study:

To summarize current knowledge on astrocyte development.
To identify challenges and limitations in studying astrocyte development.
To highlight novel approaches and technologies for advancing astrocyte research.

Main Methods:

Literature review of astrocyte development.
Analysis of existing research methodologies.
Discussion of emerging technologies in neuroscience research.

Main Results:

Astrocyte development is a complex, multi-stage process.
Significant knowledge gaps exist regarding specific molecular and cellular mechanisms.
New technologies offer unprecedented opportunities to study astrocyte development in vivo and in vitro.

Conclusions:

Further research is needed to fully elucidate astrocyte developmental trajectories.
Overcoming current technical challenges will accelerate discoveries.
Advancements in technology promise to revolutionize our understanding of astrocyte biology and function.