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Small-molecule PROTACs: novel agents for cancer therapy

Yichao Wan1, Chunxing Yan1, Han Gao1

  • 1Key Laboratory of Theoretical Organic Chemistry & Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation & Functional Application of Fine Polymers, School of Chemistry & Chemical Engineering, Hunan University of Science & Technology, Xiangtan, Hunan, 411201, PR China.

Future Medicinal Chemistry
|April 10, 2020
PubMed
Summary

Proteolysis-targeting chimeras (PROTACs) offer a novel approach to selectively degrade target proteins. This review highlights small-molecule PROTAC advancements and their potential in cancer therapy.

Keywords:
E3 ligasesPROTACsanticancerprotein degradationsmall-molecule inhibitors

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