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Updated: Dec 24, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of isoquinolones by visible-light-induced deaminative [4+2] annulation reactions
Yating Zhao1, Chengcheng Shi, Xing Su
1College of Chemical and Material Engineering, Quzhou University, Quzhou, 324000, China. liveagain@126.com.
Abstract:
Herein a metal-free approach for the synthesis of isoquinolone derivatives by means of photoinitiated deaminative [4+2] annulation of alkynes and N-amidepyridinium salts is described. This protocol exhibits a broad scope and good functional group tolerance and regioselectivity under benign reaction conditions. Preliminary studies suggest that the critical amide radical is derived from the photocatalytic cleavage of the N-N bond of the N-amidepyridinium salt, which adds to the triple bond of the alkyne and undergoes the annulation process to afford the desired isoquinolones.
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