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Clonidine for pain in non-ventilated infants
Olga Romantsik1, Maria Grazia Calevo2, Elisabeth Norman3
1Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Paediatrics, Lund, Sweden.
The Cochrane Database of Systematic Reviews
|April 10, 2020
Summary
No studies met inclusion criteria for clonidine use in neonates. There is currently no evidence to support or refute its use for managing procedural, postoperative, or clinical pain in newborns.
Area of Science:
- Neonatal care
- Pain management
- Pharmacology
Background:
- Critically ill neonates experience significant procedural and clinical pain.
- Clonidine is used in pediatric and neonatal populations as an adjunct to reduce opioid/benzodiazepine doses or aid ventilation weaning.
- Premedication with clonidine may positively impact postoperative pain in children.
Purpose of the Study:
- To evaluate the benefits and harms of clonidine for pain management in non-ventilated neonates.
- Assessed clonidine's efficacy in preventing or treating procedural pain, postoperative pain, and pain from clinical conditions.
Main Methods:
- Comprehensive search of CENTRAL, MEDLINE, Embase, and CINAHL databases up to March 2020.
- Included randomized controlled trials, quasi-randomized trials, and cluster trials.
- Data extraction focused on pain outcomes and risk of bias assessment using the GRADE approach.
Main Results:
- A total of 3383 references were identified.
- No completed studies met the inclusion criteria for the review.
- Three trials using clonidine for spinal anesthesia were excluded.
Conclusions:
- No studies were found that met the inclusion criteria for this review.
- There is insufficient evidence to recommend or refute the use of clonidine for pain management in neonates.
- Further research is needed to establish the safety and efficacy of clonidine in this population.
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