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Updated: Dec 24, 2025

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Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
Published on: June 21, 2018
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Plasma Lactate as a Marker for Metabolic Health
Nicholas T Broskey, Kai Zou1, G Lynis Dohm
1Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA.
Exercise and Sport Sciences Reviews
|April 10, 2020
Abstract:
Blood lactate concentrations traditionally have been used as an index of exercise intensity or clinical hyperlactatemia. However, more recent data suggest that fasting plasma lactate can also be indicative of the risk for subsequent metabolic disease. The hypothesis presented is that fasting blood lactate accumulation reflects impaired mitochondrial substrate use, which in turn influences metabolic disease risk.

