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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Updated: Dec 24, 2025

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
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Reprogramming Tumor Microenvironment with Photothermal Therapy.

Qinglian Hu1, Zemin Huang1, Yukun Duan2

  • 1College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

Bioconjugate Chemistry
|April 10, 2020
PubMed
Summary
This summary is machine-generated.

Photothermal therapy (PTT) reprograms the tumor microenvironment to enhance cancer treatment. This approach uses heat from light to destroy cancer cells and potentially activate the immune system.

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Immunotherapy

Background:

  • The tumor microenvironment (TME) critically impacts cancer progression and treatment outcomes.
  • Reprogramming the TME is a promising strategy to augment conventional cancer therapies.
  • Photothermal therapy (PTT) offers a noninvasive approach with high precision and low drug resistance.

Purpose of the Study:

  • To review recent advancements in PTT focused on TME remodeling.
  • To guide the development of nanoparticles for cancer photoimmunotherapy.

Main Methods:

  • Review of current literature on PTT and TME interactions.
  • Analysis of PTT's effects on cancer cells, extracellular matrix, and vasculature.
  • Exploration of hyperthermia-induced immune activation.

Main Results:

  • PTT effectively ablates cancer cells via localized hyperthermia.
  • PTT modulates the TME by disrupting the extracellular matrix and tumor vasculature.
  • Cancer cell death induced by PTT can stimulate an anti-tumor immune response.

Conclusions:

  • PTT is a versatile modality for cancer treatment through direct tumor ablation and TME modulation.
  • Targeted nanoparticle design is crucial for optimizing PTT in cancer photoimmunotherapy.
  • Reprogramming the TME with PTT holds significant potential for improving therapeutic efficacy.